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[习惯性流产]

转载,翻译研究论文集- 流产的原因,治疗方法等

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所有资料来源于谷歌流产研究论文集:
https://sites.google.com/site/miscarriageresearch/

1 是什么导致流产(这里我挑一些主要的说):
https://sites.google.com/site/miscarriageresearch/what-causes-miscarriage
  • chromosomal abnormalities of the fetus (causes 50% to 80% of first trimester miscarriages)
  • 50-80%的初期流产是由于胎儿染色体异常,所以就不用强求了。

  • feeling stressed (associated with a 200% higher risk of miscarriage)
  • 压力大会导致流产的概率增大2倍。

  • low folate levels (47% higher risk of miscarriage)
  • 叶酸过低

  • having both low folate and low vitamin B6 levels (causes a 310% increased risk of miscarriage)
  • 叶酸和维他命B6都低的话会让流产概率增大310%

      exercising
one hour a day or more during the first 18 weeks of pregnancy (270%
higher risk of miscarriage; however,
there are opposing studies regarding exercise)

      对于运动过量这一点没有定论

  • ovulating before day 11 (causes 122% higher risk of miscarriage) 
  • ovulating after day 16 or before day 12 (100% increased risk)
  • 过早或过晚排卵
  • being overweight (causes a 67% higher risk of miscarriage) 
  • being underweight (causes a 70% increased risk)
  • 体重过高或过低
  • being 30-35 years old (12% increased risk)
  • being 35-39 years old (causes a 39% to 75% higher risk) 
  • being over 40 years old (162% to 400% increased risk)
  • 年龄越大越容易出问题
  • high free testosterone levels (all subjects with free testosterone 1.30% and higher miscarried, none lower than .70% miscarried)
  • 睾丸素过高,各位妈妈不要太man了
  • low progesterone levels (found in 17% to 35% of women with recurrent miscarriage)
  • 黄体酮低
  • having Factor V-Leiden gene mutation (causes a 1% higher risk of miscarriage) 
  • having the MTHFR gene mutation (450% to 530% increased risk) 
  • having a partner with the MTHFR gene mutation (130% higher risk)
  • having thyroid antibodies (causes a 173% increased risk of miscarriage) 
  • having a proinflammatory immune milieu
  • 父母染色体异常,建议去做染色体检查。


怎样预防:

  • consume chocolate (causes a 17% lower risk of miscarriage)
  • 吃巧克力
  • consume cheese (causes a 50% reduced risk) 
  • consume milk (40% lower risk) 
  • consume eggs (causes a 30% reduced risk) 
  • eat a high fiber diet
  • 吃芝士,牛奶,鸡蛋,纤维素
  • eat fruit (causes a 46% to 70% lower risk of miscarriage, depending on the study) 
  • eat fish (leads to a 30% lower risk of miscarriage)
  • eat poultry or fish twice a week (leads to a 15% lower risk) 
  • eat vegetables (causes a 40% reduced risk of miscarriage)
  • 多吃水果,鱼,蔬菜
  • conceive either one day before ovulation or on the day of ovulation (57% lower risk) 
  • 排卵前一天或这当天受孕
  • have morning sickness (70% lower risk of miscarriage; risk goes down as severity of nausea goes up) 
  • 孕吐厉害的不容易流产
  • feel happy (causes a 60% lower risk)
  • 保持心态良好
  • consume fish oil
  • 吃鱼油
  • exercise (lowers risk of miscarriage of a healthy fetus by 40%; however, there are opposing studies)
  • 适量运动


关于黄体酮保胎:

https://sites.google.com/site/miscarriageresearch/supplements-and-miscarriage/progesterone-cream

以下是研究结果,国内常以为吃黄体酮是过度保胎,其实美国也是这样做的,很多时候剂量比国内更大。

Supplemental progesterone reduces miscarriages 54% in women with unexplained recurrent miscarriage

黄体酮减少不明原因的习惯性流产。

Supplemental progesterone lowered miscarriage risk by 56% in women with threatened miscarriage

黄体酮减少先兆流产患者的流产概率(减少了56%,还是挺多的。)

(40 mg stat followed by 10mg twice daily) or
conservative management (control group)

上面那个研究使用的剂量为40毫克,然后变成20毫克。

Vaginal progesterone lowers miscarriage risk 24% in women with luteal phase defect

黄体酮减少了黄体期不足的患者流产的几率(减少了24%)。

No evidence that supplemental progesterone causes birth defects

Progesterone therapy is a safe and effective method for preventing miscarriage

没有证据证明黄体酮会引起新生儿缺陷。

Progesterone at 20 times the normal level, but not 2 times, may cause neural tube defects

20倍的黄体酮会引起神经管缺陷。

Progesterone pill increases thrombophilia risk

400毫克的黄体酮片剂会导致血栓问题。服用黄体酮的量请遵医嘱。





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